This study involves an initial phone call and screening visit to find out if you are eligible. We will ask you to complete 7 clinic visits over a two year period so that we can evaluate any changes.
As part of the study, we will complete several non-invasive tests like measuring your blood pressure and heart rate, height and weight, and doing tests of walking and thinking. We will collect a sample of your blood, urine and stool. If eligible after screening, participants will have more visits over 2 years and several phone calls.
Participants will be asked to have a magnetic resonance imaging (MRI) scan. MRI scans are not invasive and do not use radiation. We will also do an assessment of arterial stiffness and an ultrasound scan of your carotid arteries, both of which are non-invasive exams. We will ask ACE participants to be randomly assigned by a computer (by chance, like the flip of a coin) to a group that takes 10 mg Equol daily or to a group that takes a daily placebo.
You will receive results of some assessments, will be compensated for your time and, if needed, transportation can be provided at no cost.